Since I’m experimenting quite often with my tmux.conf I want to reload the config easily. This is why I have a command to reload my config on r:

# reload config file (change file location to your the tmux.conf you want to use)
bind r source-file ~/.tmux.conf

Another thing I personally find quite difficult to remember is the pane splitting commands." to split vertically and % to split horizontally just doesn’t work for my brain. I find it helpful to have use characters that resemble a visual representation of the split, so I chose | and - for splitting panes horizontally and vertically:

# split panes using | and -
bind | split-window -h
bind - split-window -v
unbind '"'
unbind %